Gene information
Official symbol ROS1
Official full name ROS proto-oncogene 1, receptor tyrosine kinase
Gene type protein-coding gene
Chromosome6q22.1
Alias symbolMCF3; ROS; c-ros-1
Gene familyReceptor tyrosine kinases; Fibronectin type III domain containing
Resources
Entrez Gene 6098
HGNC HGNC:10261
Ensembl ENSG00000047936
Vega OTTHUMG00000016188
UCSC uc003pxp.2
GO terms: 19 records
GO Description Category LogP Number of genes Detail
GO:0001558 regulation of cell growth GO Biological Processes -19.1123936 65 More
GO:0002064 epithelial cell development GO Biological Processes -8.05661081 27 More
GO:0002065 columnar/cuboidal epithelial cell differentiation GO Biological Processes -7.52899002 17 More
GO:0004672 protein kinase activity GO Molecular Functions -2.03527804 36 More
GO:0006468 protein phosphorylation GO Biological Processes -5.36604576 56 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0019199 transmembrane receptor protein kinase activity GO Molecular Functions -5.31743835 14 More
GO:0019902 phosphatase binding GO Molecular Functions -2.86314983 18 More
GO:0019903 protein phosphatase binding GO Molecular Functions -3.28869574 16 More
GO:0030855 epithelial cell differentiation GO Biological Processes -14.2408795 69 More
GO:0032006 regulation of TOR signaling GO Biological Processes -2.04363613 5 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0043235 receptor complex GO Cellular Components -19.4198369 40 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
Drug-Gene interaction
view
Related drugs: 28 records
Drug name Interaction type Source PMID View
alisertib DTC view
asp-3026 inhibitor CancerCommons view
ast-487 DTC view
brigatinib CIViC 26372962 view
cabozantinib JAX-CKBCIViC 26673800253517432737060526372962 view
cenisertib DTC view
ceritinib JAX-CKBCIViC 2852052726372962 view
chembl3397300 JAX-CKB 27780853 view
crizotinib inhibitor TALCMyCancerGenomeJAX-CKBDoCMCIViCCancerCommonsMyCancerGenomeClinicalTrialPharmGKBTTDFDAOncoKB 29596029237249142526430525733882248758592535174325922291222157482568815726372962256672803098007129333528 view
cyc-116 DTC view
entrectinib inhibitor JAX-CKBCIViCPharmGKBFDA 2693970430425456300503032645776428183697 view
foretinib CIViC 2568815726372962 view
hesperadin inhibitor DTC 19035792 view
ilorasertib DTC view
jnj-7706621 DTC view
lorlatinib inhibitor JAX-CKBCIViCPharmGKBTTDFDA 257338823017104827401242 view
mln-8054 DTC view
neflamapimod DTC view
osi-632 DTC view
pf-00562271 DTC view
procysteine TTD view
r-406 DTC view
repotrectinib inhibitor CIViC 30093503 view
rg-1530 DTC view
sb-202190 DTC view
sns-314 DTC view
tafenoquine TTD view
tozasertib DTC view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
NG_033929.1:g.129835C>G genomics myocardial infarction[diagnosis] myocardial infarction Zee RY et al. J Thromb Haemost. 2006
NG_033929.1:g.129835C>G genomics myocardial infarction[diagnosis] myocardial infarction Shiffman D et al. Am J Hum Genet. 2005
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